Epic Stories ‘Paradise Lost’ and ‘The Ramayana’ Essay

‘The Ramayana’ and ‘Paradise Lost’ hold stories of ancient times that tend to explain the existence of two different cultures in the present world. Milton, the author of ‘Paradise Lost,’ concerns himself with the Christian story of the ‘Fall of man’ while Valmiki, the author of The Ramayana, tries to bring out an explanation to the goals of human life. In this assignment, I would like to compare author’s use of two female characters in both ‘The Ramayan’ and ‘Paradise Lost’ as I try to explain the mythological themes expressed in these two old myths (Jung 64). Eve in ‘Paradise Lost’ and Sita in ‘The Ramayan’ are the two female characters used extensively by the authors in these separate stories in an attempt to explain the goals of human life and likewise the reason for the fall of man. The story exhibited by Milton in the book ‘Paradise Lost’ has been told in countless stories and also portrayed in pictures in most religious places as well as paintings to that effect. Similar stories that relate to the book ‘The Ramayana’ can as well be found in Classical mythology (Fryer 233). Jung explains the term myths to be fatal experiences whose effects are normally felt in personal life. He classified myths according to its unconscious nature because he believes that by doing so, they will be accepted by the society hence help shape their traditions and culture. The contents of the personal unconscious are chiefly the feeling-toned complexes while the contents of the collective unconscious are known as archetypes (Jung 66). Different interpretations have been made in relation to the Garden of Eden story with most Christians holding the belief that it was actually true, another interpretation tries to portray it as a story that shows transition in t he way of life of the ancient people while a final interpretation tries to show that the truth behind the myth is baseless, though universally people live in accordance to the values it shows (Fryer 248). According to the unconscious nature possessed by people about myths is what constitutes  complex feeling-tones of individual’s private and personal psychic life. Eve, in the book ‘Paradise Lost’ has widely been regarded as the symbol of unconscious. She is seen as the figure of the animating principle and also as one that develops the growth of this principle. Franz holds the same view and explains further that she makes us believe that life may be lived. He says â€Å"Eve is full of traps and snares and in order for man to fall, he should ensnare himself there, reach the earth and stay caught so that he should live a full life† (Jung 68). This he believes that Eve accomplished by not resting until she had convinced Adam of the goodness of the forbidden apple. Eve does not see the apple as evil but as an opportunity to become wiser (Franz 56-74). Empson argues that Eve sees the eating of the apple as a test of her courage to break the commandment and graduate to a new stage of relationship with God Almighty (Empson 45-57). In attempting to comment on the serpent’s witty advances to Eve by explaining the good that comes with breaking the commandment and the benefits that eating the apple brings, Empson agrees that Eve feels that she has to break the commandment so as to show her courage and whether her desire to get to Heaven is real enough to call her courage out. He does not accept the notion that Eve is a female symbol that is used to bring out the unconscious belief in the book ‘Paradise Lost’. Empson differs with Jung’s belief of viewing eating of fruits as a sign of new beginning of life. According to Empson, the test is rooted in hermeneutics. He believes that the reason why Eve disobeyed God was because she thought God never meant what he said (Empson 122-247). The two, Empson and Jung, though both believe that Eve’s contribution to the fall is due to her desire. She does not choose to eat the apple because it is evil, but because it is an opportunity to attain another good in the book ‘Paradise Lost’, Milton differs with his predecessors who had also written stories about Adam and Eve. Milton predecessors portray Eve as deficient in virtuous enterprise. They blamed Eve for the woes of the world and their concept of Eve rooted in dualism, a view that is not depicted by Milton in the book ‘Paradise Lost’. Milton, represent Eve as a literary figure separating her from primitive conception by those who hold on tradition yet they are unconscious of prime examples of Eve in the society. ‘Paradise Lost’ is a literary epic of a personal effort while ‘The Ramayan’, however, is a non-literary epic. Sita is the dominant female character in the story ‘The Ramayana’ and thus is comparable to Eve in ‘Paradise Lost’ in their contribution to bringing the mythical themes to the two stories as they are both mythical symbols. ‘Paradise Lost’ is a work of a single individual and thus it is possible to conclude that the characters involved in the story are a projection of the author’s ideas on how he wants the characters to appear. It can thus be said that the characters in ‘Paradise Lost’ are truly Milton’s characters. This cannot be said of the characters in the epic story ‘The Ramayana since it is a collective effort of different people in bringing out the epic story. It is due to this that the comparison of the two primary characters in the two separate stories becomes interesting . Sita is first introduced in the epic story at Janak’s wedding. She is regularly referred to as faithful, gentle, soft and sweet. In the epic story, a marriage of husband and wife is regarded to as a linkage. This resembles the marriage as depicted in the bible in the book of Genesis, where Adam is quoted as referring to Eve as ‘flesh of my flesh’. The epic story also shows man as superior to the woman, as it indicates that the woman is the shadow to the man’s masculine substance. Sita’s limitation occurs when she gets obsessed with her attraction to the deer’s beauty that she sends Rama out to go and look for it. Her obsession is magnified when she gives an option that if Rama cannot catch the deer alive, then at least he brings her the deer’s body so that she may use it as a rag. Rama becomes angry after Lakshman refuses to obey his orders when she sends him out to look for him. Her desire exposes her to Ravan’s desires which force him to kidnap her and carry her away with him to Lanka. This situation is in sharp contrast to that of Eve in the epic story ‘Paradise Lost’. In ‘The Ramayana’, Sita’s fall is her desire for a good that is illusory which separates her from Rama her protector and thus becomes vulnerable to capture, while to Eve, it makes her vulnerable to temptation by the serpent which later leads to her eating of the apple. The two scenarios depict the same theme content, and that is a woman’s desire that leads to unfortunate endings. In the case of ‘Paradise Lost’, the eviction from the Garden of Eden, while in ‘The Ramayana’, a war ensued. The contrast in the way the two characters are shown in the two epic stories is also different. The author individualize Eve right from the start of the book however in the case of Sita, the author individualize her after the incidence where she became angry with Lakshman for not obeying her when she sends her to go fetch Rama. Of the two, Eve as portrayed in the book ‘Paradise Lost’ is in contrast with how she has always been portrayed by people generally and other poets too. She is shown as an object of desire, her work in the garden and her sexual relations with Adam. She is thus the author’s portrait of an ideal woman with an exception being her desire for knowledge which indicates her as a cultural symbol. Sita on the other hand is more of an ideal character. The psychological reality that is shown by Sita’s story and her loss is evident too in other classical myths and is also present in the Biblical myths of the Garden of Eden. The nature of ‘The Ramayana’ epic story also helps in suppressing many other author’s ideals and aspirations as it is a collective work of individual elements. The analysis of the two characters gives the conclusion that a character’s thematic condition is reliant on the poet’s capacity of showcasing his own ideals. Works Cited Dutt, Romesh. The Ramayana and the Mahabharata. London: Dent, 1910. Empson, William. Milton’s God, London: Chatto & Windus, 1961. Franz, M,-L. ‘The Process of Individuation.† Man and His Symbols. ed. Carl G. Jung. New York: Dell, 1964. Fryer, Northrop. Anatomy of Criticism: Four Essays. Princeton: Princeton University Press, 1957. Jung, Gustav. The Archetypes and the Collective Unconscious. Princeton: Princeton University Press, 1969. Milton, John. Paradise Lost; An Authoritative Text, Backgrounds and Sources, Criticism. Ed. Scott Elledge. New York: Norton, 1975.

BDO Cash Management Essay

BDO Cash Management Solutions provide a diverse range of financial solutions that can be customized to meet even your most demanding and complex financial needs. With BDO, you have cash management solutions you never thought possible. The BDO services at your disposal: Payables Solutions Integrated Disbursement Solutions – Provides greater efficiency by consolidating all payment transactions Payroll – Maximizes the convenience of paying employees’ salaries, benefits and incentives Check Disburse – Streamlines and customizes your check printing and preparation Government Payments – Gives you convenience in paying various government agencies using BDO’s Online Banking Service Receivables Solutions Auto-Debit Arrangement – Simplifies and ensures on-time collection of receivables Bills Payment Facility – Efficiently facilitates collection and consolidation of payments from your clients through BDO’s various channels Cash & Check Deposit Pick Up – Provides peace of mind by securing your collection by utilizing armored cars or authorized couriers Post Dated Checks Warehousing – Offers safe and automated management of future-dated check collections Point Of Sale Terminals – Cost effective and efficient alternative to cash-based collections At BDO, we know you have banking needs that can be vastly different from others’ and minutely specific to your operations. This is the compelling reason why we have put together a diverse range of banking products and services to provide the best solution possible for your specific banking need. Currently, BDO’s Cash Management Solutions offers 18 products to serve the cash management needs of over 7,000 clients. The effectiveness of CMS can be seen in its average annual growth of 20% and P130 million average annual growth. Our track record has also gained the recognition and respect of foreign banks as many have made BDO their preferred partner to service their clients in the Philippines. Dedicated support groups, including the Operations team, the Implementation team and IT group work together to provide seamless service solutions you probably never thought were possible. — Copyright @ https://www.bdo.com.ph/business/cash-management

Elie Saab Designer Analysis

ELIE SAAB Lebanese designer Elie Saab has long been a leading name in haute couture in the Middle East, where his romantic, crystal-encrusted gowns attracted princesses to his Beirut atelier, opened in 1982 when he was just 18 years old. His ready-to-wear line, which launched in 1998 in Milan, heralds the same feminine aesthetic as his couture dresses, with brightly colored silks, chiffons, pearl beading, and embroidered lace. With their Middle Eastern detailing and European sensibility, Saab gowns are also at home on the Hollywood red carpet.Halle Berry famously wore one of Saab’s designs to pick up her Academy Award for Monster Ball in 2002. Many other celebrities have been seen wearing his designs including Rachel McAdams, Mila Kunis, Taylor Swift, Beyonce, Rihanna, and many more. Born in 1964 in Lebanon, Elie Saab is a self-taught fashion designer. His interest in dressmaking started at the young age of nine. Saab spent much of his free time cutting patterns and drawing sk etches for his sisters, using his mother’s tablecloths and curtains.The neighbors soon got wind of what he was up to, and by the time he was a teenager he already had a small network of loyal clients. Looking back, Saab says, â€Å"I was born with this passion of creating and making dresses and was always surrounded by beautiful women, from sisters to neighbors, so the desire to dress them and make them look elegant was my constant inspiration. † In 1981 he moved to Paris to study fashion, but ended up returning in 1982. That year, at just 18-years-old, Elie Saab opened his Couture Atelier in Beirut, managing over a dozen employees, he was already a master in the art of dressmaking. In 1997 Saab was the first nonItalian designer to become a member of the Italian Camera Nazionale della Moda, and in 1997, showed his first collection outside Lebanon in Rome. In 1998, he started ready-to-wear in Milan, and in the same year, he held a fashion show in Monaco which was attend ed by Princess Stephanie of Monaco. In May 2003, the Chambre Syndicale de la Haute Couture invited him to become a member, and he showed his first haute couture collection in Paris in July of 2003.His first readyto-wear collection in Paris was the Spring/Summer 2006 collection, and Paris is now his permanent ready-to-wear runway. Beirut remains Saab’s main source of inspiration. In 2005, he inaugurated a modern fivestory building where the workshops are now located, along with his studio, ready-to-wear boutique and haute couture showroom. The atelier is where all of the haute couture gowns are made and pass through the hands of Elie Saab himself. Elie Saab’s target customer is certainly woman of status. All of his designs are hand made making them very expensive.He only has two shops carrying his haute couture lines. They are in Paris, France, and Beyrouth, Lebanon. His ready-to-wear lines on the other hand, can be found in multiple places in over 30 countries includin g the United States. Saab’s accessories are more like his haute couture gowns in that they are much harder to come by, they can only be found in Lebanon, the United Arab Emirates, France and the United Kingdom. The most accessible item from Elie Saab would be his perfume, which can be found at Nordstrom, Saks, and Neiman Marcus stores across the country. Saab’s collections are glamorous and sophisticated, fusing a cultural myriad of fashion influences to give a distinctive and modern edge to his designs. His signature elements are definitely his very feminine, flowing gowns. He experiments with the central themes of femininity and romanticism, creating clothing that is cut-to-the-curve, with soft edges and exquisite detail including hand embroidery, beading and the use of luxurious fabrics such as mousseline and silk.He is scrupulous with his intricate detailing. A writer at Women’s Wear Daily stated, â€Å"He likes sexy, embroidered gowns. Period. Sequins†”the more the better. Flounces, fringes and everything that glimmers—give him more. † It is very true, if Saab’s designs aren’t dripping with sparkling embellishments they are meticulously embroidered. Saab creates fairytale designs whilst always maintaining a delicate sophistication. There is always some incredible detail on the dresses really displaying the designer’s talent.When Elie Saab was asked to dress Belgian Countess Stephanie de Lannoy for her wedding to Luxembourg Crown Prince Guillaume it was no surprise for he has known the bride for eight years. The amount of effort he put into the dress was astounding and from Saab, one would expect nothing less. A writer from Women’s Wear Daily stated, â€Å"The dress required 3,200 hours of work and embroidery, and 700 hours of sewing by a team of 10 seamstresses and 15 embroiderers. De Lannoy’s wedding dress was embroidered with 200 transparent sequins, more than 80,000 different transparent crystals and 50,000 small beads.All that finery needed more than 10,000 meters of silver-plated thread, according to Saab. When all was said and done, the gown called for 50 meters of Chantilly lace, 40 meters of Calais lace, 30 meters of satin organza, 70 meters of 4 tulle, silk crepe for the lining, and 15 meters of silk tulle for the veil. † [1] Further proving his commitment to his work and his ability to create incredible designs to not only make any woman feel like a princess, but to actually fit a princess for her own wedding.Saab doesn’t do much to advertise his clothing. Besides runway shows he get’s all of his business from celebrities who already wear his designs and others who see the designs on those celebrities. Halle Berry accepting the oscar for â€Å"Best Actress in a Leading Role† wearing one of Saab’s designs made him an overnight success in the red carpet world. Since that day, it is nearly impossible to find a red ca rpet event without an Elie Saab design being worn. Taylor Swift is one of Saab’s most loyal customers.She has been spotted wearing his designs on multiple occasions on and off the red carpet. Elie Saab’s biggest competitors are Versace and Valentino. All three designers attract a similar clientele with their haute couture gowns. They have similar styles as well, all being very well versed in creating gowns that flatter a woman’s body and show a soft feminine side, but in my opinion Saab is the epitome of femininity. He just completely understands how to create a a breathtakingly beautiful and elegant design.Anyone celebrity wanting to impress on the red carpet with elegant beauty would know to go to Elie Saab. Personally, I have never seen an advertisement for Elie Saab designs but I am always blown away at his gowns on the red carpet. His knowledge of the female figure and how to flatter it is amazing. His gowns always cut in at exactly the right spot to make e very woman look beautiful. The market segment Saab is definitely missing out on is the middle class however. In a way, this doesn’t really matter because most of his designs, and the ones he is most famous for 5 re his haute couture gowns, which not many people other than celebrities or high-status socialites have a reason for wearing. One way I would remedy this divide however, would be by offering Saab’s bridal gown line in more wedding boutiques across the country. Although Saab’s wedding gowns start at around 10,000 dollars, many women are willing to spend huge amounts of money on their weddings, especially their dresses, so I think this would be a perfect way to reach a larger audience plus it would be great for more middle class women who still love and appreciate Saab’s gorgeous designs.Another way Elie Saab could reach the market he is missing out on would be to create a line similar to the Marc by Marc Jacobs. I more affordable line that could be carried in the same department store that already carry his perfume. With the way Saab has been able to expand his fashion empire in such a short amount of time, this more accessible line seems like the logical next step. There is no question that Elie Saab is an incredible fashion designer but he is also an incredible businessman.Today, the 46-year-old runs a truly global empire, with boutiques in Paris, London and Dubai. His clothes are on sale in 22 countries, and he has moved into bags, shoes and jewelry. But that is just the start: in recent years, Saab has expanded into designing the interior for the BMW X Series, worked with MAC Cosmetics and has also signed a deal to design three mega yachts. There is no question that his talents span far past just dress making. Elie Saab’s exquisite eye for detail, knowledge of how to flatter a woman’s figure and business savvy make for an incredible combination.The designer has already made such huge strides in the business in such a small amount of time, there is no question in my mind that Elie 6 Saab will continue to expand his fashion empire. There is really no limit for a man with the talent Saab possesses. 7 1. WWD Article Elie Saab Tapped for Royal Wedding By ROSEMARY FEITELBERG FROM: WWD Issue 10/25/2012 THE COUNTESS BRIDE: For Elie Saab, dressing Belgian Countess Stephanie de Lannoy for her wedding Saturday to Luxembourg Crown Prince Guillaume was not an overnight occurrence — he has known the bride for eight years.The dress required 3,200 hours of work and embroidery, and 700 hours of sewing by a team of 10 seamstresses and 15 embroiderers. De Lannoy’s wedding dress was embroidered with 200 transparent sequins, more than 80,000 different transparent crystals and 50,000 small beads. All that finery needed more than 10,000 meters of silver-plated thread, according to Saab. When all was said and done, the gown called for 50 meters of Chantilly lace, 40 meters of Calais lace, 30 met ers of satin organza, 70 meters of tulle, silk crepe for the lining, and 15 meters of silk tulle for the veil. Saab said, â€Å"We met several times to discuss the design of her gown. At first, she explained to me what she had in mind and I came back with different sketches. She then selected one of them and we started working on it, choosing the different fabrics, color, and adapting the design. † The designer was with his own wife, Claudine, and one of their sons at Luxembourg’s Notre Dame Cathedral when the bride and groom exchanged their vows last weekend. 9

Geography Essay Example | Topics and Well Written Essays - 750 words - 2

Geography - Essay Example The religious aspect does not play a big part, despite members of each side being Islamic, Christian, or other religious beliefs. It is a war between the Arab and non-Arab groups. The conflict in the Sudan has been raging for years. The Afro-Arab factions along with the Sudenese government to conquer a new rebel groups in Dafar called Sudan Liberation Movement (SLM) and the Justice and Equality Movement (JEM) which are made up of non-Arab Muslims. Both factions are black. The Sudanese government which is Arab has been targeting non-Arabic Africans for years. However when the SLM and JEM started fighting back the bloodshed intensified. The Sudanese government has not entered into the fight directly, but has funded the Janjaweed. The Janjaweed is considered a terrorist group in the West. Accusations of genocide have been directed at the Janjaweed. Due to the Sudanese government support of the Janjaweed, not much has been done to rectify the situation. The skirmishes and killing continue despite peace treaties and ongoing talks. Arabic Muslims believe that non-Arabic Africans is inferior to them. They believe that all ‘black’ non-Arabic Africans should be slaves. This history goes back to Arabic Muslims selling non-Arabic Muslims and non-Muslims to slave traders. Although the Arabic faction of the Sudan is lighter than the non-Arabic faction, both are still black. The Arabic faction does not see the darker non-Arabic as the same color or race. The darker Africans are inferior and meant to be slaves. As mentioned before religion does not play a big factor in this conflict. Going back to the slave trade days, the non-Arabic people were sold into slavery even if they were Muslim. Alex Hailey’s ancestor in Roots was a devout Muslim. However due to the color of his skin, Kunta Kinte was captured and sold to slave traders. He did not understand why men the same color as him could sell a brother into

Evaluation of Canons Strategies Essay Example | Topics and Well Written Essays - 2000 words

Evaluation of Canons Strategies - Essay Example This mixture demands continuous and effective flow of information and the ability to adapt to change. All members of the company should be involved and strategy, when needed, needs to be changed accordingly. Robust measurement of strategic competences is critical. Canon has applied strategic planning since 1957. The strategic approach to achieving top market position involved everyone and there was a careful planning of the resources needed in order to achieve the market position. Canon has focused on the photocopying market in the beginning and it has focused on niche marketing i.e. producing small photocopiers. It has in parallel, developed new technology. Starting from photocopiers, Canon has developed since then core competencies in printers, scanners etc. The company emphasized customer satisfaction and it is customer oriented. Based on customer satisfaction, it has developed its growth plan which is called â€Å"Excellent Global Corporation Plan†. In this plan, the goal of Canon is clearly stated i.e. top share and profitable operations. The strategic planning process involved: highly automated manufacturing plant, high –technology products and synergy. So, the structure of Canon’s strategic plan was the following: the centre set the long-term strategy whereas the business units (product divisions) implement medium-term planning acting always within the constraints placed by the centre. Crisis management and contingency planning were important in Canon’s strategic process since the company wanted to be prepared in case of adverse events. These various plans were consolidated by the centre. Each business unit/division prepares its own budget, these budgets are gathered and then the centre prepares short-term plans. The company culture is quite distinctive: people are encouraged to talk and debate. The emphasis on people is shown in the objectives of Canon for the years 2001-05 among other objectives such as product leadership, development of R&D and strong financial position.  Ã‚  

Design an e-Business System Essay Example | Topics and Well Written Essays - 3500 words

Design an e-Business System - Essay Example Proper communication remain essential in ensuring the minimisation of errors; hence improvement of the business process. The utilisation of an internet based system for establishing links between salesmen, customers and suppliers remains essential in improvement of the processes. The different stakeholders will access information from a central source, and share information from the same centre. This sharing can effectively improve business processes and increase the company’s market share. Objectives The main purpose of the subsystem remains ensuring quick transfer of information and sharing between various stakeholders. The system aims at improving the business process and increasing efficacy of the process of making sales and manufacturing. Improvement of these processes can result in increased sales owing to the reduced time taken in making orders and delivering supplies. The application of the system objectives can ensure the company sales increase significantly, ensuring the company achieves significant growth. Background Avitz Bike is a UK based manufacturing company which specialises in different types of bikes for different markets globally. While the company experiences a considerably good market share, stiff competition has resulted in reduced market share over the last 5 years. This reduction has been attributed to the duration taken before bikes are delivered to customers. The company relies heavily on sales made through different retailers across the United Kingdom. While the utilisation of retailers has continuously provided sufficient market-share, improvement in the selling process remains inevitable as the company seeks to increase sales. The utilisation of an E-business system seeks to ensure the company reduces the delivery time for most products. This would effectively increase the current sales volume, consequently increasing the market share. The company has adopted the E-business strategy to eliminate the lengthy supply chain, pre sent in the current strategy. Description of the business process The process of receiving orders within the business involves direct communication with retailers, through telephone, electronic data exchange of facsimile. The retailers first make contact with sales managers, to negotiate on different product prices, before making orders to the company. The orders are then subjected to a validation process, which includes verification of various order requirements as stated by the retailer. This validation process results in acceptance or rejection of the order. Following the validation of different orders, required parts can be orders to enhance the assembling of the requested bike. The customer specifications determine how the distributors deliver bikes to various retailers. When utilising process, the company does not make direct contacts with the customers making the process lengthy. The company utilises an information system developed in 1997, built on LAN with Windows NT as the client-server system. The current system contains information regarding customers, suppliers, bikes and other physical attributes of company products. Some of the information contained within the system remains available to specific departments, an aspect which causes delays. Problems and solutions in project that the company is facing The company faces a number of challenges resulting from the current business process and information systems. The biggest problem

Financial Anaylsis of ASMAK Company Research Paper

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Indonesia Term Paper Example | Topics and Well Written Essays - 2250 words

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HRM Practice Essay Example | Topics and Well Written Essays - 1000 words

HRM Practice - Essay Example This kind of behavior not only posed a threat to the reputation of the company but the unregulated stream of affairs also affected the children in a negative way. Motivation theories state that different factors affect why people go to work and their performance and efficiency is determined by these factors. These could be fulfillment of physiological, security, relationship, self esteem or self actualization needs according to Abraham Maslows hierarchy of needs. Other motivational factors would include Expectancy, Instrumentality and Valence according to Victor Vrooms theory of motivation. Absence of these factors of motivation could easily lead to low performance and efficiency. Absenteeism would have been a problem if employees were assigned fixed days but since the job demanded a fixed number of hours therefore employees preferred to report to the institution but work with a lax attitude. The low performance levels at social service could also be directly linked to the job characteristic model. Workers should be enthusiastic about the job they perform. They should have a certain level of intrinsic motivation which is related to the skill variety, task identity and task significance. Feedback from a job and consequences and results of workers activity also result in work effectiveness. Absence of these would decrease performance. It could be clearly observed that most of the motivational factors were absent from the job. The workers or the employees were not receiving any direct monetary compensation from the job and were ignorant about its true purpose; the betterment of the society. Thus they could not relate to the real intention of the job. There was a pressure to attend but there was no regulator of the quality of work. There was absolutely no job related instrumentality of social work as there were no identifiable outcomes in form of promotions or

Cigarette Ads Essay Example for Free

Cigarette Ads Essay From 1947-2000 cigarette ads have changed in more than just one way. Each ad pinpoints a certain stereotype of a person as well as containing a slogan that assures the viewer of which stereotype the ad is pertaining to. Each ad does a great job of matching the slogan with the image, while drawing in consumers and maintaining the fulfillment of the consumer’s prefrence. The ad used in 1947 for Camel cigarettes claims â€Å"More Doctors smoke Camels Than Any Other Cigarette†. The ad also contains a picture of a man posing as a doctor. The picture as well as the slogan being claimed, provides a sense of comfort and safety. People may think if doctors are smoking these cigarettes they may not be unhealthy. This ad could also come off as an ad promoting the â€Å"need for prominence†, while aiming to represent the cigarette of those of a high social status (Fowles 549). The Camel ad also slightly resembles a news article as and is layed out in a very informative manner, while pointing out all of the benefits of the product. This approach is common because potential consumers are often looking for a new solution† (Bovee 559). If a consumer is looking to become more healthy, or attempt to feel less guilty when smoking a cigarette, this ad may attract their attention, simply due to the fact that the ad claims it is the number one cigarette for doctors. The Marlboro ad of 1970 pertains to those who prefer a cigarette that contains a great amount of flavor. The slogan states â€Å"come to where the flavor is. Come to the country†. This ad’s main attraction is the flavor of the cigarettes, which pertains to the â€Å"need for autonomy† due the fact that this ad appeals to those who prefer a cigarette with great flavor(Fowles 550). Not only does this ad have to do with the need of autonomy it also pinpoints the â€Å"need for affiliation†, it is obvious the ad is affiliated with those who not only enjoy flavor but also enjoy being in the country, the slogan as well as the picture is what make the two main attractions obvious in the ad (Fowles 544). The camel ad of 2000 is most likely going to attract those who wish to attain the perfect cigarette, therefore this ad pertains to the â€Å"need for aesthetic sensation†, due to the fact that this ad is a simple ad with few words , there is little room for correction nearly being a perfect ad(Fowles 552). This ad will not only attract people’s attention because of the word â€Å"pleasure† being placed in the slogan, but also the picture is an attention grabbing picture. The ad contains a picture a young, fit, attractive male, which also means this ad pertains to the â€Å"need for attention† (Fowles 550)Not only does this attract people’s attention it is also desirable. Over the past years the cigarette ads have slightly changed. The pictures, slogans, and the layout have all changed over time, but only to a slight extent. Although the physical appearance of the ads may have changed slightly over time, the idea of advertising cigarettes have not. Just as Fowels said, â€Å"most advertisments appearing in national media can be understood as having two orders of content† (Fowles 541). All the ads serve the same purpose, while each ad does appeal to different types of people, each ad also does the same thing to attract a certain type of person or idea. This is done by placing certain words as well as images to draw in consumers. As consumer’s wants as well as needs change, ads continue to change accordingly. With this being said, most changes that do occur are often subtle, therefore the changes that have been made in ads are often very slight. When major changes are made to ads, it is often due to the fact of improvement of the product or to fulfill a major want or need of the majority of the consumers.

Fast Food Industry study of Pizza Hut

Fast Food Industry study of Pizza Hut Introduction A major transformation in business management is that organizations are trying to optimize every aspect of business. There has been a keen focus into every aspect of business which can give the organization a price or quality edge over its competitors. Effective Supply chain management (SCM) is capable of both the above mentioned advantages. If we look into the various components of SCM and analyze their significance in the context of the above we find that they are quite significant and capable of achieving price and quality edge over competitors. In this research the focus will be to study various factors influencing the supply chain management in fast food industry by referring to Pizza hut. The aspects associated to price quality and customer satisfaction will be covered through this research. The fast food industry has seen huge transformations in the recent past; the affect of these transformations on the supply chain management is also discussed in this research. Background As we know that supply chain manages the entire materials from suppliers (Suppliers of raw materials to the organization) to retailers and distributors to the customers. There are various disciplines involved in this system. for example the supplier relations management, inventory management, distribution system, retail management, reverse supply chain management. It has been observed that action in one discipline can influence the performance of the whole chain and similarly the performance of the organization. (T.J. Peters 1982à Ã‚ ¾ Riddalls 2002). More and more organizations / industries are identifying the significance of supply chain management. In terms of research there are three most researched issues in the whole supply chain management, they are; Information flow through supply chain Inventory / warehouse Management Operations Management (queuing system) The fast food industry is one of the most competitive industries. The competition majorly depends upon price, quality and service (which are core aspects of Supply Chain Management). Hence there is immense pressure on all the organizations in the fast food industry to keep the three aspects studied above to their supreme best. As fast food industry is one of the most emerged industries in the recent past, the supply chain has seen huge transformations in this industry. The industry is still emerging so as the transformations in the supply chain management of this industry. Hence this study helps the learner identify and understand the factors driving change and the factors influencing the supply chain performance. Few of the research questions and research objectives are underpinned; Research Questions This research will not only try to present the study associated with the title of the research but will also try to answer the questions mentioned below; What is the core meaning of supply chain? What is the significance of Supply Chain Management in fast food industry? What are the major components of Supply Chain Management? How significant is information sharing to keep the supply chain effective? What factors influence / drive supply chain management in fast food industry? How is demand forecast supply managed accurately? What is the impact of supply chain management on overall performance of Pizza Hut and in creating brand name for Pizza Hut? How does Pizza Hut manage their SC effectively? Similarly the research has set few objectives for itself to achieve in the course of this study. The research objectives are mentioned underneath; Research Objectives Aligned with research questions we have set few objectives for this research. They are listed underneath; To understand the supply chain practices in fast food industry To understand the difference between SCM practices in fast food industry and in other industries (manufacturing Service sector) To prove that effective core competencies can lead to competitive advantage Identify significance of various parties in the supply chain on the performance of the supply chain To understand the service level impact on the supply chain The organization / company chosen for this research Pizza hut was started in the year 1958 by two brothers Dan Frank Carney. This was an idea suggested by a common friend which they agreed to. In 1972 they introduced corporate strategy. In the mid 90s the profits of Pizza Hut were declining. Hence Dan Frank Carney thought of selling out the company. In the year 1997 Yum! Brands acquired pizza hut and is currently (Pizza hut) under Yum! Brands Highlight of Pizza hut is its variety in Pizza, garlic bread, pasta and breadsticks. In order to meet the production of the mentioned (menu) products pizza needs to co-ordinate all the suppliers of vegetables, chicken and bread and work in coordination with them. Keeping this aspect efficient is the key success factor of Pizza Hut. As we know that if an organization can manage its core competencies effectively they can surely act as competitive advantage for the company. As the ingredients for various products of pizza hut are acquired through various suppliers from different parts of the globe. There has to be proper communication to keep the supplies and demand under check. In order to keep this aspect effective the company has employed Total Quality Management (TQM) process. The strategic policy of Yum! Brands involve the suppliers to understand their role and impact in the overall performance of the organization. This keeps the supplier relations management aspect in place for the organization. Pizza Hut has restaurants and they also deliver their products to customers place. The supply chain in these cases differs. If it is served at the restaurant then it usually shortens the supply chain and if the product (pizza, pasta etc), then the supply chain has transportation included in the supply chain. Both these aspects will be discussed in detail in this study Limitations of the study As the research focuses on the supply chain management of fast food industry, there may be few differences in the supply chain then the supply chain of other industries. This research does not specifically answer questions which are out of the industry / focus of this research. The supply chain of fast food industry keeps changing in short intervals. We have focused this study on supply chain of Pizza hut. This may answer the general questions with the supply chain of fast food industry but may not answer the specific questions of other organizations. Literature review Supply chain plays a critical role in maintain the organizations brand image and service levels in the market. In this section we will speak about Supply Chain Management (SCM) in general first and then will confine it to the fast food industry. Supply chain is the term used to define the parties involved in the process of meeting customer demand. The parties involved in the supply chain are Suppliers Manufacturers / producers Distributors Retailers customers (Riddalls, C.E., Bennett, S., 2002) (Stanley E. Fawcett and Gregory N. 2004) A brief of their role in the supply chain in underpinned; As we know that supply chain management is a discipline that manages and controls the flow of information throughout the various departments to meet the customer demands. The supply chain starts from the extreme beginning of the manufacturing process i.e. acquiring the raw materials from the suppliers or in other words choosing the suppliers and ends at the extreme end of the production process i.e. the customers. (Raghavan, N.R.S., Viswanadham, N., 2001) The members or parties of the supply chain are briefed below; Suppliers: suppliers are a significant party in the supply chain. The raw materials are supplied / acquired through this resource. In terms of quality of materials / products the suppliers are held responsible. The price of the product depends upon the price of the raw material as well and the supply of raw material will influence the companys ability to meet the customer demand at the right time. Hence we can say that suppliers have a great impact on the price of the product and companys ability to meet the customers demand on time. (Riddalls, C.E., Bennett, S., 2002) Manufacturers / Producers: These are the members who convert raw materials / semi finished goods to finished goods. The production process is significant as the company judges the quality and attributes of the process in this phase; hence manufacturers also influence the quality of the product. (Riddalls, C.E., Bennett, S., 2002) Distributors: These are people who are responsible to make the product reach to the market (retailers). The distributors can be also termed as marketing intermediaries. There are various aspects associated with marketing of a product and choosing the right distributors. The reach of the distributor will always be directly proportional to the availability of the product in the market. (Riddalls, C.E., Bennett, S., 2002) Retailers: These are people who are at the end of the supply chain. In other words these are the people who sell the product to the customers (supermarkets, stores etc). They are one of the significant members in the supply chain as they are in direct contact with the customers. They represent the product on behalf of manufacturer to the customers. The demand and customer feedback can be analyzed at this level. (Riddalls, C.E., Bennett, S., 2002) Customers: These are the end users of the products. Customers were not considered as a part of supply chain, but the contemporary methods and study has added customers into the supply chain. (Riddalls, C.E., Bennett, S., 2002) The significance of these parties in the supply chain varies in context to industries. Few of the terms involved in SCM are underpinned; Inventory size This helps the organization decide the amount (size) of inventory to be ordered. This is one of the significant aspects in the fast food industry as this helps the organization not only order the right quantity but also meet the customers needs with minimum resources possible. (Raghavan, N.R.S., Viswanadham, N., 2001) Replenishment Lead Time This refers to the time between placing an order and acquiring the raw material. Usually lead time is always considered as an entity that makes the supply chain ineffective (loss in supply chain). (Raghavan, N.R.S., Viswanadham, N., 2001) Stock outs Stock outs are very common in every trade. This is a situation that arises due to miscommunications in supply chain parties, lack of analysis, bad demand and sales forecasting. Safety stock This is the excess stock that a firm maintains to manage demand fluctuations. The safety stock is maintained at the lowest levels as most of the firms are efficient in sales forecasting. Reorder Point This is a point in inventory levels wherein the firm feels the need to order more inventories. SPECIFIC TO FAST FOOD INDUSTRY Fast food is referred to food which can be cooked easily and can be eaten quickly. There are various food chains across the world, which are famous for fast food. If we look into the history of the fast food industry, the roots of fast food are from 1920s and from 1950s this industry saw a rapid growth. There are many reasons for this transformation in food habits of people. People were busy and did not find time to cook food or even to wait for long hours after ordering food. There arose the term fast food. The Asians (Specifically Chinese) are responsible for this term and industry. There lies the secret behind the customer expectations. Customers expect food to be served quickly, should be delicious and should be healthy. In this scenario all the parties of the supply chain play a major role in meeting this expectation. (Tony Hines, 2004) Few of the objectives of supply chain management in fast food industry are mentioned underneath; Supply chain planning This sets the chain direction and the strategies associated with all the aspects of supply chain. This is the overall sketch of the supply chain. (David Simchi-Levi, Philip Kaminsky and Edith Simchi-Levi, 2004) Procurement This is the process of selecting a supplier and managing healthy and profitable relation with them. This also helps the organization maintain quality of their products. (David Simchi-Levi, Philip Kaminsky and Edith Simchi-Levi, 2004) Inventory management This process helps the organization maintain right level of stock in the organization and eliminate stock outs with variation in demand for the product. (David Simchi-Levi, Philip Kaminsky and Edith Simchi-Levi, 2004) Packaging This is a discipline that helps in ensuring right package design and reducing the cost by encouraging the recycling process of packaging. (David Simchi-Levi, Philip Kaminsky and Edith Simchi-Levi, 2004) Warehousing This is the process of storing the raw material, semi finished and finished goods. Effective storage and correct warehouse design can reduce the overall cost of the product (eliminates transportation cost to a certain extent) and improve the availability of the product. The other factors in this discipline are safety of the product, storage methods and locations of the warehouses. (David Simchi-Levi, Philip Kaminsky and Edith Simchi-Levi, 2004) Transportation This process refers to transportation management of goods. This includes all the possible modes of transferring goods from one location to another. The records maintenance are also included in this aspect. (David Simchi-Levi, Philip Kaminsky and Edith Simchi-Levi, 2004) Logistics This is referred to the use of technology in maintaining all the disciplines of supply chain effectively. The use of softwares is a trend in logistics management (CRM softwares). (David Simchi-Levi, Philip Kaminsky and Edith Simchi-Levi, 2004) Customer Service and marketing This refers to meeting the customer expectations effectively and creating new opportunities through customer service. This is one of the major aspects that organizations are focusing in contemporary business world. (David Simchi-Levi, Philip Kaminsky and Edith Simchi-Levi, 2004) The entire above mentioned are effective ways to remain competent, exist and grow in the market. Therefore managing supply chain effectively can help the business prosper. There are few other associated concepts which have an influence on the supply chain, one of them is Bull Whip Effect. Bull Whip Effect This is referred to sudden increase in customer demand that forces the supply chain to reconsider its strategy and rearrange the stocks in the supply chain. This forces the management to include more stocks into the system to meet the increased product demand. The Bull whip effect always flows in reverse direction to the flow of products. I.e. starting with realtor and ending it with the supplier of raw materials to the manufacturers. (Raghavan, N.R.S., Viswanadham, N., 2001), (Peter D Ball, 2006) There are various reasons of Bull Whip Effect; few of them are mentioned underneath; Under estimation of demand Wrong sales report Inefficiencies Lead time management Miscommunication in the supply chain (Peter D Ball 2006) Hence we can say that effective communication (information flow) in the supply chain is significant. The fast food industry cannot store the stock (Raw materials) in advance. Most of the products are vegetables and souses, which need to be fresh. Hence effective supply chain management is required. It has been observed that the major focus of most of the fast food chains is to improve the service levels (quality of the product and delivery time to the customers). Recently it has also been observed that in developing countries such as India, Pakistan, Srilanka and others, the fast food industry is focusing on the quantity and price factors. Once again this can be achieved through effective supply chain management. Research methodology Research methodology plays a vital role in the outcome of every research. There are various aspects, which a researcher needs to consider, before during and after gathering data for a research. Few of the aspects are presented underneath and are discussed in the context of the research. (Cooper, D. Schindler, P. 1998) Research approach There are various research approaches possible. Few of them are underpinned; Inductive approach Deductive approach Qualitative approach Quantitative approach (Saunders, M., Lewis, P. Thornhill, A. 2003) A brief of the above four is given below; Inductive approach: The term itself indicates that this process starts with a point and ends up adding information and few more points on the way through to making general interpretations about the research topic. (Saunders, M., Lewis, P. Thornhill, A. 2003) Deductive approach: This refers to an approach that starts with few concepts and theories and tries to confine the subject in the context of the research focus. This is one of the widely used approaches to reach to a conclusion in general researches to add more specific information to existing concepts. (Saunders, M., Lewis, P. Thornhill, A. 2003) Qualitative approach: This approach relies on the existing theories and practices. In other words this approach is based on the tested and proven methods. The available literature is the major source in this approach. This is called qualitative as the research results can be more reliable then compared to other methods / approaches of research. (Saunders, M., Lewis, P. Thornhill, A. 2003) Quantitative approach: This is one of the widely used research approaches. This approach relies on a wider study and does not majorly rely on the literature, instead will take a concept or theory from the existing literature and will research about it in the environment (surroundings). This is one of the approach used to make general interpretations about a concept or theory. The major methods of this research approach are surveys, questionnaire, interviews etc. (Saunders, M., Lewis, P. Thornhill, A. 2003) The research approach for this research will not be restricted to any of the research approaches. We will use all the approaches possible to keep this study effective. As there are various factors influencing the supply chain and the fast food industry is specific, hence we will try to emanate the drawbacks of various approaches and will use all possible methods to gather pertinent and result oriented data. Research Strategy Research strategy for every research is significant. As we know that this influences the outcome of the research, hence we have decided to formulate two questionnaires for gathering data. One will focus on the management and the other will focus on the experiences of the customers. This will also help in covering all the aspects in this research. For this research we will also contact few industry experts to analyse the interpretations and results of the research to keep it effective. Data sources There are various sources through which data can be gathered. The data for any research can be divided into two categories. They are; Research specific data (Primary data) Supporting data (secondary data) The above two are explained in brief below; Research Specific data This is also known as primary data. The term itself indicates that this data is specific to the research. The data that is gathered to answer the set research questions is known as primary data. The major sources for gathering data in this category are interviews, focus groups, surveys, observations, questionnaires, telephonic interviews, etc (Bryman, A. Bell, E. 2003) Supporting data This refers to the data that fills the gaps left by the primary data. As the major function of this data is to support the research, hence this is known as supporting data. This data is not research specific, instead is gathered from the available literature or some other pertinent research. The major sources through which this data can be gathered are academic books, magazines, newspapers, internet, etc (Bryman, A. Bell, E. 2003) The data for this research will be gathered through formulating two questionnaires and using two methods. First we will try to contact the management of Pizza hut through email and take their responses on the questionnaire; the second will be to carry-out a general survey in public to know about the customer service (and associate it with the effectiveness of the supply chain). We will also utilize the secondary sources such as Internet to gather pertinent data to make the research effective. Data Analysis There are various aspects that a research needs to focus before, during and after gathering data for a research. These aspects help the researcher keep the data effective in the context of the study. Few of the aspects are listed below; Validity: This refers to the relevance of variables in the study. As we know that there are various variables in a research. This aspects ensures that the data gathered should be relative to the research. In other words these aspects state that there has to be inter-connectivity between the focus of the research and the data gathered. (Ghauri, R. Gronhaug, K. 2005) We will try to gather relevant data and will avoid vagueness in data. The data gathered will be confined to the research focus but will also try to remain neutral to answer various other research associated questions. Reliability: This aspect refers to neutral (correct or accurate) and bias free results. In other words this aspect states that if the same data is used again for a similar research the results of the research should be similar. This also states that there should be any biased interpretation or should be a favor for any person or organization through this research. (Ghauri, R. Gronhaug, K. 2005) We will not only stay neutral while interpreting the findings and framing the results of this research, but will also send the results to few industry experts to seek their view. This will eliminate the bias aspect from the research and will keep the research effective. Generalizability: This refers to the spectrum covered by the research answers in resolving the general issues. In other words the results of the research should be able to answer a wide range of real time issues. (Ghauri, R. Gronhaug, K. 2005) We will try to keep the results as general as possible and will also try to cover as many issues as possible. Authenticity of data sources: This is one of the significant aspects of any research. The data gathered should be from reliable sources. The authenticity of data sources defines the effectiveness of the research. (Collis, J. Hussey, R. 2009) We will try to gather data from authentic sources. As we have formulated questionnaires and are gathering data through sources which are reliable, I believe we can surely guarantee the authenticity of data sources. Ethical Issues This refers to the methods used for gathering data. The ethical issues are quite significant for every researchs credibility towards the society. This includes a code of conduct that states that the methods used for data gathering and research should not include any method that is illegal or unacceptable. The methods or results of the research should not harm any person / firm / industry. (Crowther, D. Lancaster, G. 2009) The methods used for this research will be decided by keeping the above code of conduct in mind and will not include any such methods which fall out of the code of conduct. We will try to keep the work ethical and free from any bias. PROJECT PLAN Weeks 0-2 3-4 5-6 7-8 9-10 11-12 13-14 15 Background Reading Research Proposal Theoretical framework Primary Secondary Data gathering Report Making Submission Conclusion Supply chain management plays a significant role in managing resources and effective customer service irrespective of industry. The fast food industry is customer driven and the service level plays a significant role in creating expectations with the customers. The fast food industry (Specifically Pizza hut) will be studied in the context of the supply chain extensively and the research results will be framed. We will study all the associated aspects and will try to cover all the potential issues under the focus of the research. We will keep the research bias free and ethical to the extreme possibility.

What Genetic Factors Contribute to Obesity?

What Genetic Factors Contribute to Obesity? Obesity has increasingly become a challenging epidemic and is now a global concern which has shown no sign of lessening (McAllister et al, 2009, p. 868). While considerable efforts have been invested in stressing the importance of physical activity and the choice of food intake, studies have shown compelling evidence that genetic determinants brought by the inter-individual differences have high responsibility in obesity susceptibility (ORahilly Farooqi, 2006, p.1095). Substantive evidences about the molecular constituents of the major pathways involved in the balance of mammalian energy have only been recently deciphered. Therefore, this provides a gateway to a mechanistic understanding of obesity that will soon be a useful resource in the designing of effective drugs against obesity. Linkage studies and associations based on populations have identified specific loci where genetic variations occur among obese individuals. Efforts to indentifying and characterizing the monogenic obe sity syndromes have also shown considerable success (ORahilly Farooqi, 2006, p.1095). While a number of researchers have come into a consensus that genetic factors predispose individuals to obesity, some still slightly differ by appreciating the role of such factors like the influence on metabolic rate as well as the effect of selective partitioning of the excess energy in the human body into fats (ORahilly Farooqi, 2006, p.1095). This paper specifically identifies various genetic factors which contribute to obesity and provides recommendations for addressing the epidemic. To date, there are five main constituent genes known to be involved in food intake and energy expenditure pathways which ultimately contribute to obesity progression. These genes are leptin, leptin receptor, melanocortin-4 receptor, pro-opiomelanocortin as well as prohormone convertase genes (Bouchard, 2009, p.1499). The role of these genes in the occurrence of obesity and mutation consequences of such genes, wh ich are studied in different experiments, are elaborated and explained under different gene headings below. Leptin gene Efforts to perform leptin gene cloning in 1994 opened an avenue for rapid research in biomedicine and large scale genetic studies followed thereafter (Hinney, Vogel Heberbrand, 2010, p. 297). Finally, these efforts made success stories after effectively managing to treat leptin deficiency children using the recombinant leptin protein. The treatment of leptin deficiency children also provided other insights to biomedical researchers that single gene mutations could potentially lead to disorders such as obesity and hyperphagia (Hinney, Vogel Heberbrand, 2010, p. 297). Since its discovery, leptin has posed a potential possibility for the treatment of obesity. The development of obesity treatments has been centered in identifying main targets in leptin gene which was the first to be implicated for the genetic cause of obesity. The leptin hormone is mainly secreted depending on the body fat and is responsible for the regulation of appetite and energy metabolism mainly in the brain (Ahim a, 2002, p.196). Results obtained from linkage studies have deciphered that leptin is basically an assembly of 167 different amino acids that are produced by the leptin gene right from the adipose tissue. The protein encoded by the leptin gene displays a number of biological roles associated with obesity by binding with a defined receptor located in the hypothalamus. These biological roles of leptin include the control of food intake pathways, body weight regulation and homeostasis of energy (Wang et al, 2006, p.183). French studies and investigations into populations in Pennsylvania have associated leptin to cases of severe obesity. Among humans, the chromosomal locations of the genes for leptin receptor and leptin have been mapped to 1p31 and 7q31.3 respectively (Wang et al, 2006, p.183). Research had earlier shown that the variant G-2548A occurring in the LEP promoter was responsible for reductions in the BMI among overweight women. In addition, a few studies have shown correlati ons between obesity development and the presence of LEPR gene polymorphisms (Geller et al, 2004, p.572). According to Ioffe, Moon, Connolly and Friedman (1998, p.11852), subset of obese humans have considerably lower levels of leptin plasma. The findings imply that abnormal regulation of the gene in the adipose tissue could be the main cause of pathogenesis in obesity. Ioffe et al (1998, p.11852) carried out an experiment to test the propensity that decrease in the production of leptin could impact the bodys metabolism thus cause obesity. They performed their experiment by mating animal models that carried lowly expressed adipocyte specific aP2-human leptin transgene with mice that did not express any leptin gene. The leptin treatment of the mice that never expressed leptin resulted to a marked reduction in weight which resembled the results obtained after wild-type mice treatment. Usually, a subset of obese individuals expresses relatively low levels of leptin in plasma. The decreased rates of leptin production among obese individuals by the adipocytes have been implicated for the caus e of obesity (Ioffe et al, 1998, p.11854). Mutations in the leptin gene or the leptin receptor gene have been found to cause increased appetite, overeating, massive weight gain, impaired thermoregulation, insulin resistance and diabetes, immune dysfunction, sexual maturation failures and a number of neuroendocrine derangements in both human subjects and rats (Ahima, 2002, p.196). Melanocortin-4 receptor gene (MC4R) Mutations in the melanocortin 4 receptor have been said to be the most common genetic factors which contribute to obesity. While the gene coding for the protein, MC4R has been implicated for regulating the body weight of individuals and obesity, there are no convincing reports associating the gene with the increased binge eating among obese individuals. Contrary to what had been observed in the previous studies, the MC4R deficiency does not actually cause hyperinsulinemia. However, a frameshift mutation in the gene coding for the protein MC4R has been associated with dominant human obesity (Hinney, et al, 2003, p. 4258). The protein also acts as an antagonist for the agouti-related peptide (AgRP) gene that code for an endogenous antagonist for the receptor. The homologous of the MC4R gene, the MC3R gene has also been found to be a good candidate for causing genetic susceptibility to glucose intolerance in type II diabetes mellitus (Hinney, et al, 2003, p. 4258). In order to prove tha t MC4R is influential in causing obesity, researchers have sequenced the introns of the gene among the Pima Indians who among them, 300 were severely affected by obesity and 126 of them were neither obese nor diabetic. In their study, the researchers have addressed the assertion that substitution of G-A at codon 103 of the MC4R gene is responsible for influencing abdominal obesity and lipid, glucose and insulin metabolism. The substitution has also been implicated for its effect in inflecting the circulatory hormones such as the salivary cortisol (Hinney, et al, 2003, p. 4260). Genome wide association studies (GWAS) have been potential tools for identifying a number of candidate genes in specific regions of the chromosomes which harbor genes responsible and other phenotypes (Zlot et al, 2007, p.31). GWAS also provide critical tools for indentifying the common variants with reduces penetrance relevant as traits of interests or risk factors. Genes such as melanocortin-4 receptor gene occur in a coding region which also harbors other polygenic variants which regulate weight in healthy individuals apart from the mutations responsible for obesity (Yang et al, 2002, p.20328). These minor alleles that have been identified include various polymorphisms which code for isoleucine amino acid instead of valine at position 103 (103l) and the other that codes for leucine instead of isoleucine at 251L of the receptor protein. These polymorphisms are all negatively associated with the problem of obesity (Zlot et al, 2007, p.31). Homozygous carriers of such alleles have sli ghtly reduced basal metabolic rate (BMI) which is a risk factor for obesity. The biological mechanism of the MC4R gene has been suggested to involve the activation of the MC4R receptor which leads to a significant decrease in food intake. The MC4R has therefore been marked as the main therapeutic target for obesity treatment. The new regulatory biological mechanism has also been detected in cell lines which are derived from the murine hypothalamic neurons that express MC4R endogenously. This therefore points to the physiological importance of the endocytosis promoted by AgRP. In a study involving a number of obese children and adults, 6 percent of them were found to posses MC4R SNPs (Zlot et al, 2007, p.29). Following agonist stimulation, the MC4R usually signals via the intracellular adenylate cyclase pathway of signal transduction. Studies among the obese subjects have detected large quantities of MC4R mRNA in the membranes of the astrocytes contrary to the HEK-rMC4R cell membranes. Pro-opiomelanocortin (POMC) Feeding in humans follows habitually trained rhythms which are regulated by the hypothalamus. The amount of food one consumes happens as a response to the energy status in the body that depends on the hormones. Even though this is a complex process, there exists an integrated relationship between the energy needs of the body and the amount of food that is required by the body. As a result, the brain through the hypothalamus triggers the release of responsible hormones that regulate food intake. This happens through the release of pro-opiomelanocortin (POMC) (Millinvgton, 2007, p.4). The initial stage of the production of pro-opionmelanocortin starts with the production of the release of the POMC at the hypothalamus. Through a series of active enzymatic reaction steps, the pro-opiomelanocortin (POMC) plays an initial role in the production of corticotrophin (ACTH), melanocyte-stimulating hormones (MSH) and endorphin (Millinvgton, 2007, p.4). The MSH leads to the production of melanocortin peptides that plays a high role in the development of appetite. The melanocortin peptides also continue to have a role in body weight regulation. As the body continues to produce the necessary genes that regulate its development, some genes that develop in the central nervous system give rise to the production of the melanocortin peptides. According to Zemel and Shi (2000, p.179), melanocortin peptides work by coating the melanocortin-4 receptors through the formation of a layer around these receptors. This covering inhibits the food absorption and intake. The absence of this through the degeneration of the melanocortin peptide cover marks the onset of obesity. This means that melanocortin receptors POMC peptide s plays a significant role in the development of obesity. As seen earlier, feeding is a process that happens through responses of habitual rhythms such as circadian rhythms. These rhythms are controlled by the genes that are adapted to a given type of system. The lack of POMC in the body exhibits itself through adrenal failure, altered pigmentation and increment in height onset of obesity (Millington, 2007, p.8). The processing of POMC occurs partially in the pituitary cells and neurons of the hypothalamus. However, POMC derivatives can be discharged differently through varying hypothalamic sites. These are sites that are involved in feeding process. This process of release leads to slight variations in the amount of signal sent to the sites. From the above discussion, dietary related aspects especially obesity emanates from a complex combination of various genes that makes their significant contributions. Environmental factors are also known to have their equivalent contributions to the role of the genes in the dietary habits and their effects on the body. The melanocortin that is produced as a result of POMC stimulation plays a central role in the direct processes of food absorption. Additionally, the signals sent by the POMC maintain the hormonal levels that controls amount of food to be absorbed at any given moment. This is depending on the homeostatic energy requirement at any specific time. However, in the instance when the levels of POMC released by the hypothalamus get reduced to minimal levels, the immediate effect that follows is the reduced production of melanocortin peptides. This means that the body no longer has the ability to control the amount of food being taken up by the body. Obesity develops as a resul t of the body absorbing food at a higher level than required. Prohormone convertase 1 (PCSK1) Researchers have reported that common variants in the PCSK 1 gene could be a potential cause of obesity. The proprotein convertase subtilisin/kexin type 1(PCSK 1) has been suggested to play a critical role in proteolytic cleavage, a step which is also important in the maturation process of a number of hormones which are produced as precursors (Heni et al, 2010, p.86). The PCSK 1gene codes for the prohormone convertase 1 which is actively involved in peptide maturation. The protease is selectively expressed in the endocrine and neuronal tissues where its main substrates include the hormones which regulate energy metabolism such as proinsulin, proopiomelanocortin and proglucagon (Heni et al, 2010, p.86). Rare mutations in the PCSK 1 gene have been identified to be responsible for causing childhood obesity as well as the abnormal metabolism of glucose, proinsulin and insulin and the C-peptide. Common single nucleotide polymorphisms (SNPs) in the PCSK 1 gene, the rs6232 and rs6235 have b een associated with incidences of obesity (Heni et al, 2010, p.86). Various mutations of the PCSK1 gene cause monogenic obesity. The SNP rs6235 has a high correlation to the non-synonymous rs6234 which encodes the Q665E. This substitution occurs at the protein in the C-terminal region (Tuomas et al, 2009, 3499). This research found that there exist a significant correlation between age and crs6232 in the initiation and proliferation of obesity (Tuomas et al, 2009, 3499). Another research by Qibin et al (2010, p.456) found that the rs6234 has significant association with an increased risk of a combined obesity phenotype and an overall overweight condition. The PCSK 1 gene was also found to have a higher association to obesity among men as compared to women. The result of this gene is that it influences the increment in fat storage around the waist region. The study also found that there exist enough evidence that associates PCSK1 rs6234 with overweight and the level of body mass index in men. It was also revealed that PCSK1 rs6234 plays no role in the weight gain among women. There have been various recommendations in the use of several mechanisms in the management of obesity. This has been based on the knowledge of the fact that eating habits are part of acquired characteristics. However, studies have revealed that eating habits are controlled by genes. This has therefore called for more understanding on the gene make up of a person. The understanding of the role of PCSK1 gene in the control in insulin and consequent glucose synthesis is a breakthrough in the ongoing research in the search of the appropriate weight management measures. Studies conducted by Martin et al (2010, 9) have found that small amounts of alleles of PCSK1 and SNPs are associated in high levels of stimulation of glucose proinsulin levels. This gave an indication that the two are related in the reduction of proinsulin conversion with little effect on insulin itself. Under the normal conditions, prohormone convertase cleaves a substantial amount of proinsulin. The study further found that PCSK1 and SNPs alters the sequence of the amino acid sequence of the protein which makes up this hormone. The change that is initiated by the SNP rs6232 on asparagines is the reduction of the enzymatic activity. The similar change also occurs on the location of the protein thereby reducing its effectiveness in regulating insulin. The end result is the increment of body weight, a condition that is referred to as obesity. Fat Mass and Obesity Associated Gene (FTO) The FTO gene has also been identified, using the GWAS approach, to be associated with type II diabetes and obesity. The A-allele of the FTO variant rs9939609 in intron 1 has been shown to be associated with an increased risk to develop obesity complication by 31 percent (Hinney, Vogel Heberbrand, 2010, p. 302). The association of genes in obesity and overweight problems has been suggested to be high in both monogenic obesity and polygenic forms. The FTO gene is one of the best examples of the common variants which play a role in increasing the BMI and thus important among obesity individuals. The FTO gene is known to be found in chromosome 6 among humans and variants of the gene have closely been associated with human obesity. The gene is widely distributed in both adult tissues and fetal tissues but there is much expression in the pancreatic islets as well as in the hypothalamus. Transcribed amino acid sequence of the FTO gene has shown high homology with AlkB, an enzyme which demethylates DNA oxidatively. The FTO recombinant protein has the potential to catalyze 3-methylthymine demethylation in single-stranded DNA. Animal studies have shown that gene expression in FTO is usually upregulated in rats especially in the hypothalamus following food deprivation. The gene is also negatively correlated with the orexogenic galanin like peptide expression that is commonly involved in food intake stimulation. The increase in the expression of hypothalamic FTO is often associated with energy intake regulation but not the feeding reward. These consequences make the gene to be identified as a critical in causing obesity. An obesity risk allele of the FTO variant has been identified. Usually, the carriers with a single copy of the FTO allele are more susceptible to develop obesity than individuals without the copies. In another observation, the carriers of the two copies of the FTO gene weigh even more than those with a single copy of the gene. This implies that the gene causes an increased risk of obesity among the carriers compared to those without a copy of the gene. At the same time, researchers have identified the association of the single nucleotide polymorphisms (SNPs) in the similar region (rs14210850) of the FTO gene. The variation has been identified as the cause for some percentage of population variance in BMI and even a higher number of attributable obesity cases. The risk allele, according to the researchers, is found in cluster 10 SNP in intron 1 of the FTO gene known as the rs9939609. Morbid obesity has also been shown to be associated with both the INSIG2 SNPs and the FTO gene. Varian ts of the FTO have also found to be associated with the obesity condition using GWAS of BMI. In the study, individuals with AA and AT alleles at rs993909 have been found to consume more energy per day compared to the individuals having the protective genotype of TT. However, the similar studies have indicated no variation in energy expenditure based on polymorphisms. In other studies, the consequences of variations in the two different types of SNPs in the FTO gene have shown the possibility of the gene impacting the levels of circulating leptin as well as the energy expenditure. The SNPs that affect the energy expenditure and the circulating levels of leptin include the rs1421085 and rs17817449. Although the studies have not pointed on the biological mechanisms of the FTO gene in contributing to obesity and weight control, researchers have postulated that the gene could be responsible for regulating appetite through its influence in the hypothalamus. Discussion and Recommendations The pathogenesis of complex diseases such as obesity has always been associated with the interaction of environmental and genetic factors. This complexity has made it difficult for researchers to tease apart the accurate relationship between the genotype, phenotype and environmental factors by only using conventional experimental designs. Using genetic information maintained in databases, researchers have been able to identify critical molecular pathways responsible for obesity which are specifically brought by the interaction of the environmental factors and the genetic factors (Gohlke et al, 2009, p.46). Bioinformatics techniques and the Internet have offered critical tools for synthesizing data on the relationship between genes and diseases such as obesity. Methods such as genome-wide association scans have shown a number of genetic variants in the FTO gene which might be associated with phenotypes related to obesity (Scuteri et al, 2007, p.115). Researchers have identified the po tential benefits of genomic-wide association studies (GWAS) approaches in obesity intervention and prevention strategies such as the design of highly specific drugs targeting the identified molecular pathways (Zlot et al, 2007, p. 31). The role of epigenetics in obesity has been explored by a number of researchers including McAllister et al (2009, p. 892). Epigenetics encompasses the study of a number of inheritable variations mechanisms in gene expression which do not necessarily originate from alterations in the DNA sequence. These mechanisms are often established at the early stages of postnatal development and during the prenatal stages and they act to maintain a number of gene expression patterns throughout the life of an individual (McAllister et al, 2009, p. 892). Because of this, some environmental factors have become common in the recent past and have commensurately deranged the epigenetic mechanism establishment which results in the regulation of body weight (McAllister et al, 2009, p. 892). The roles of cytosine methylation within the CpG dinucleotides, the modification of histone proteins which package the DNA into the nucleus and the cell-dependent expression of a number of autoregulatory DNA binding p roteins have been investigated and shown to perpetuate the conformation of regional chromatic which dictates which type of gene will be competent transcriptionally in specific type of cells (McAllister et al, 2009, p. 892). This literally implies that apart from the genetic basis of obesity, the epigenetic studies shed light and provides extra information that is layered above the common understanding of gene sequences. Like the DNA sequence, epigenetic factors are also replicated at cell division during mitosis and meiosis thus bestowing transgenerational epigenetic inheritance (McAllister et al, 2009, p. 892). As reported by McAllister et al (2009, p. 896), the understanding of the environmental factors on the epigenetic processes has always remained elementary. Therefore, there has been little evidence to point out specific environmental exposures whose increasing levels might affect epigenetic mechanisms. Maternal obesity has however been identified as one of the main environmental exposure which results into obesity. It is accepted that the obesity epidemic affects even the childbearing women and feed-forward transgenerational obesity amplification has been proposed to result among children born of obese mothers. This is because the intrauterine environments of obese mothers are likely to induce developmental adaptations in the developing fetus which consequently predispose them to obesity. In an observation made to support this assertion, children born of obese mother after bariatric surgery were found to have reduced risks for obesity than the children born of the same mothers before bariatric surgery (McAllister et al, 2009, p. 893). Bariatric surgery is one of the medical procedures carried out with an objective of losing weight and has shown exciting evidence in reducing the chances of obesity among the born children. There are two types of disorders that have been identified to be caused by single-gene defects. The first class of these disorders is the Mendelian disorders which cause a variety of clinical features including obesity. The second class of single-gene defects is mainly characterized by disease conditions in which obesity is one of the main clinical features. 11 different genes have been reported to be closely associated with monogenic obesity and 52 genomic regions which harbor quantitative trait loci have also been indentified to have associations with human obesity. Five of the genes have been considered to be of clinical importance since they account up to 5 percent of the early obesity onset and severe cases of childhood obesity. These genes are leptin, leptin receptor, pro-opiomelanocortin, melanocortin 4 receptor as well as prohormone convertase genes. One of the most interesting observations is that all the five genes are associated with encoding receptors and peptides involve d in satiety and appetite regulation. Therefore, there is need to intensify research efforts in marking the five genes and developing molecular drug targets for critical receptors which control appetite and satiety. Apart from the five common genes that have been associated with obesity, other minor genes with smaller effects such as ACE, LDLR and VDR have also been implicated for causing obesity. These minor genes are more than 20 in number (Bouchard, 2009, p.1499). Conclusion and Recommendation The prevalence of obesity is increasing globally as biomedical researchers step up their efforts to indentify the specific genetic causes of the epidemic. A number of technological and conceptual advances have made it possible for a shift to an approach centered in single-gene search for interventions aimed at treating and preventing obesity. Before these advances, traditional approaches involved studying obesity from the polygenic approach which was very difficult to mark out the exact molecular processes that occur in at cellular level. A few complex segregation analyses maintained the assertion that obesity was mainly caused by more than a single segregating genes having large effects on the adiposity and body weight. Later studies supported the evidence that obesity could be caused by both polygenic and oligogenic determinants. With the improved technology and scanning of the entire genome, it has been possible to identify individual genes responsible for obesity using polymorphi c microsatellite markers. Among the enabling technologies in sequencing the human genomes involve SNP identification, bioinformatics and SNP genotyping technologies. At present, these technologies have made it possible to study the anatomy of the human genome with improved details and this is expected to yield newer insights into pointing out the exact genetic causes of obesity.

Software Piracy :: essays research papers fc

Software Piracy: A Worldwide Problem Software piracy is defined as the illegal copying of software for commercial or personal gain. Software companies have tried many methods to prevent piracy, with varying degrees of success. Several agencies like the Software Publishers Association and the Business Software Alliance have been formed to combat both worldwide and domestic piracy. Software piracy is an unresolved, worldwide problem, costing millions of dollars in lost revenue. Software companies have used many different copy protection schemes. The most annoying form of copy protection is the use of a key disk. This type of copy protection requires the user to insert the original disk every time the program is run. It can be quite difficult to keep up with disks that are years old. The most common technique of copy protection requires the user to look up a word or phrase in the program's manual. This method is less annoying than other forms of copy protection, but it can be a nuisance having to locate the manual every time. Software pirates usually have no trouble "cracking" the program, which permanently removes the copy protection. After the invention of CD-ROM, which until lately was uncopyable, most software companies stopped placing copy protection in their programs. Instead, the companies are trying new methods of disc impression. 3M recently developed a new technology of disc impression which allows companies to imprint an image on the read side of a CD-ROM. This technology would not prevent pirates from copying the CD, but it would make a "bootleg" copy differ from the original and make the copy traceable by law enforcement officials (Estes 89). Sometimes, when a person uses a pirated program, there is a "virus" attached to the program. Viruses are self-replicating programs that, when activated, can damage a computer. These viruses are most commonly found on pirated computer games, placed there by some malignant computer programmer. In his J anuary 1993 article, Chris O' Malley points out that if piracy was wiped out viruses would eventually disappear (O' Malley 60). There are ways that a thrifty consumer can save money on software without resorting to piracy. Computer companies often offer discounts on new software if a person has previously purchased an earlier version of the software. Competition between companies also drives prices low and keeps the number of pirated copies down (Morgan 45). People eventually tire or outgrow their software and decide to sell it.

Free College Essays - Envy in A Separate Peace :: A Separate Peace Essays

Envy in A Separate Peace  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   â€Å"People are often vain of their most criminal passions; but envy is one passion so mean and low that nobody will admit it† Francois de la Rochefoucauld(1613-1680), a French philosopher, once stated and that statement summarizes the undertone of A Separate Piece by John Knowles.   The story is set at a highly competitive boy’s school on the East Coast that sets the perfect stage to develop the storyline.   Gene’s insecurity, which led to jealousy of Finny, is the cause of the overall conflict.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   In chapter 1 Finny leaps from the tree for the first time, and then Gene follows.   When Gene jumps after Finny he does it not because of being â€Å"shamed into it† (906) as Finny says but out of envy to be more like Finny.   Gene gets an odd feeling of gratification that seems to settle his insecurity when he is imitating Finny.   On the walk home from the tree Gene boasts â€Å" I then became his (Finny) collaborator† as they were both missing evening meal.   This shows that his subconscious jealousy had succeeded in being like Finny. Gene felt that the more he could associate with Finny the more he would be considered like Finny.   Even Gene may not have realized his underlying jealousy but it was there from the beginning.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Gene nears completion of his transformation into Finny in chapter 4. â€Å"I jounced the limb† (923) says Gene, and Finny falls through the branches snapping the limbs with his momentum until the fall ended with an unnatural thud. This action initiates the final phase of Gene’s plan he can not completely be Finny until the space is open and until then it was filled.   At this point Gene begins to realize what has been happening.   At the funeral Gene said that he did not cry then or ever.   Gene did not cry because he knew that when Finny was buried that was all that was buried Finny, a body.

Adavantages and disadvantages of space tourism Essay

Tourism is a worldwide popular trend .people love exploring different places by going to destinations which are alien to them. Their are various forms of tourism like ecotourism, cultural tourism, medical tourism ete.. Recently, a new type of tourism was added to list. Namely space tourism. It is just as the name suggest going to space for various purposes like leisure, business ete.. today in this article I will look at the pros and cons of space tourism. One of the main merit of tourism is that it helps to develop economy. As we all know space tourism is a very wide industry hence it will open a path for many job opportunities bringing a solution to the problem of jobless people to a certain extent. Furthermore we will get to discover a wide variety of new things. We can experience firsthand the beauty of comets, asteroids, stars and planets rather than seeing them by using a telescope, after all seeing with our own eyes have a different feel completely. In addition to this ,the fu ture of tourism will flourish. When advanced technological inventions like space shuttles and such are used a lot of people will be attracted to this industry .This is very much true right? Just imagine if we come across an event which we are not very familiar with then the tendency to learn it also grows. On the other hand, there are a lot of demerits of space tourism as well. Space tourism is quite a risky thing. No matter how developed we are if a catastrophe strikes in outer space we are not very likely to survive .moreover, it can be called simply a useless activity. Just for the mere pleasure of the eye there is no need to spend so much. It is a squander of money and time Instead, if that same amount is given to the people who are suffering from famine and natural disasters, magnanimously we can make our world a better place for people of different standards. Space tourism is also affordable to a few. Even one trip to space takes over hundred thousand dollars. This results in different problems between the rich and poor .furthermore, it gives rise to a lot of environmental problems like global warming since a lot of non renewable sources are used in this industry. Space tourism is both a boon and ban .if it is carried out carefully then it will bring about lot of benefits and if it is not carries out carefully then get ready to face the worst outcome.

Advantages and Disadvantages of CCTV Cameras Essay

CCTV Monitoring CCTV for Surveillance CCTV camera system is being widely employed as a security system for surveillance in offices as well as homes. It is used for monitoring purposes to keep a close vigil. Not only in closed or private places; CCTV camera system extends as a security system in public and crowded places like traffic intersections, malls, shops, etc. As with the case of any technology or security system device, a CCTV camera system has its own pros and cons. Advantages of CCTV Camera System 1. Deters Crime The presence of CCTV camera system for surveillance will reduce petty thefts and vandalism in shops, malls and other public places. Since the activities are being monitored, fewer nuisances are likely to be created. It also reduces the losses due to shoplifting. 2. Helps Maintain Records The images and videos captured by a CCTV camera system are often recorded and stored into a database. These are helpful in maintaining records so that they can be easily retrieved later, when needed. 3. Protects Employees This is particularly helpful in customer service centers. The employees providing customer service may sometimes be subjected to verbal abuse or physical attacks. CCTV camera system helps to identify such instances and act immediately. It is also helpful to keep a tab on the activities of the employees. 4. For Evidence in Lawsuits In legal cases of thefts and other forms of crime, videos and images provided by the CCTV camera system can serve as a valid proof and evidence against the defaulter. This assists in making legal claims as well. Disadvantages of CCTV Camera System 1. Do Not Work Always CCTV camera system cannot monitor every area of your office or home at all times. Hence it cannot be considered as a foolproof method for crime prevention. 2. Privacy Concerns Invasion of privacy is the major issue when it comes to any security system device like the CCTV camera system. It lowers the employee morale and hampers productivity at times. Constant monitoring of every activity might put the workers ill at ease. 3. Initial Costs The initial costs incurred per camera are high. The installation may also increase the initial expenditure. It depends upon the complexity of the CCTV camera system as well.